Please be patient while the object screen loads.
Please use this identifier to cite or link to this item : http://hdl.handle.net/2078.1/9448
OBJECTIVE: In mice, the renal toxicity of arsenic (As) and cadmium (Cd) has been shown to be exacerbated by the simultaneous administration of both elements. To verify the existence of such an interaction in humans, cohorts slightly (Belgian) and moderately (Chinese) exposed to both elements were examined. METHODS: Biological indicators of exposure (Cd in urine and in blood; As in urine) and renal effect parameters (retinol binding protein (RBP); beta(2)-microglobulin (beta(2)M); albumin (ALB); N-acetyl-beta-glucosaminidase (NAG) in urine) were determined and their relationships studied by multiple regression analyses. RESULTS: Changes in renal effect parameters could be ascribed to Cd body burden. RBP and beta(2)M urinary concentration were influenced by exposure to As only in Chinese women, directly and in interaction with Cd exposure. CONCLUSION: A synergistic action of As on the tubular effects of Cd is observed in women moderately exposed to these elements and leads to RBP urinary excretion slightly above normal values.
|Publication Date :||2003|
|Document type :||Article de périodique (Journal article) - (Journal Article - Multicenter Study - Research Support, Non-U.S. Gov’t)|
|Source :||“International archives of occupational and environmental health” - Vol. 76, no. 2, p. 111-20 (2003)|
|Publication status :||Publié|
|MESH :||Acetylglucosaminidase - urine ; Adult ; Albumins - metabolism ; Arsenic - adverse effects ; Body Burden ; Cadmium - adverse effects ; Environmental Exposure - adverse effects ; Female ; Humans ; Kidney - drug effects ; Male ; Middle Aged ; Proteinuria - urine ; Regression Analysis ; Retinol-Binding Proteins - urine|
|PDF_01||pdf document||292 KB||Request copy|