Devogelaer, Jean-Pierre; Azria, M; Attinger, M; Abbiati, G; Castiglioni, C; Nagant de Deuxchaisnes, C; Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue. ; 1994
Calcified tissue international , Vol. 55, no. 1, p. 71-3 (1994) doi: 10.1007/BF00310172 hdl: http://hdl.handle.net/2078.1/26384

Comparison of the acute biological action of injectable salmon calcitonin and an injectable and oral calcitonin analogue.

Auteur :	Devogelaer, Jean-Pierre ; Azria, M ; Attinger, M ; Abbiati, G ; Castiglioni, C ; Nagant de Deuxchaisnes, C

Résumé

In most countries, calcitonin is available in the form of injections, and less frequently as an intranasal spray. An oral route of administration should improve compliance. In a preliminary feasibility study, we have compared the acute biological action of injectable salmon calcitonin (50 IU), with the injectable calcitonin analogue ASC 710 (0.2 mg) and oral ASC 710 (20 mg) in 6 patients suffering from active Paget's disease of bone. The intensity and duration of the biological response were not significantly different in the 3 modes of therapy. In conclusion, the oral calcitonin analogue ASC 710 possesses an antiresorbing activity in Paget's disease comparable to that of an injection of salmon calcitonin which demonstrates that it can cross the intestinal barrier.

Informations complémentaires

Departement :	UCL - "MD/MINT - Département de médecine interne"
Type :	Article de périodique (Journal article)
MESH :	Administration, Intranasal ; Administration, Oral ; Aged ; Bone Resorption - drug therapy ; Calcitonin - administration & dosage - pharmacology - therapeutic use ; Chromatography, High Pressure Liquid ; Feasibility Studies ; Female ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Osteitis Deformans - drug therapy ;
Source :	"Calcified tissue international" - Vol. 55, no. 1, p. 71-3 (1994)
issn :	0171-967X
Texte intégral :	10.1007/BF00310172
Lien(s) :	http://www.ncbi.nlm.nih.gov/pubmed/7922793
Date de publication :	1994

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